Hello!
This is my first theory, and it's a small one. Don't even know if someone already mentioned this on another theories.
My belief is that the Room 23, that we're wondering about for 'ages', is the cure for the sickness.
It's now know that the sickness is motivated by MIB, causing the 'sick people' to change their beliefs: losing motivation to follow Jacob's will and joining MIB's.
Room 23 then plays out, with all those "Jacob" references, making the 'sick people' change hands again, being on Jacob side. So when the Others found someone that was sick (maybe this happened to Carl, who were on the jungle always running away), he was sent to Room 23 to be cured.
What do you think about this?
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